Triethylamine → (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid

Temperature

100 °C

To a mixture of (6S)-1,1-dibromo-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid (8.7 g, 21.8 mmol), 50 wt % hypophosphorus acid (25.9 mL, 9 eq) and triethylamine (44.3 mL, 10 eq) in water (104 mL, 12 volumes) was added V-50 (591 mg, 0.1 eq) in 2 mL of 50% aqueous acetonitrile. The mixture was heated at 100° C. During the heating, additional 0.1 eq of V-50 was added to the reaction mixture every 30 minutes. Totally, 0.7 eq of V-50 was added. After heating at 100° C. for 4 hrs, the reaction mixture was evaporated and treated with 2N NaOH. It was extracted with ethyl acetate (2×50 mL). The aqueous layer was acidified with 2N HCl, extracted with ethyl acetate (2×50 mL). The combined organic layers were washed with water and brine, dried (Na2SO4), filtered and evaporated to give the title compound (3.63 g, 69%) as a light yellow solid. 1H NMR (500 MHz, CDCl3): 4.51-4.42 (m, 1H), 3.48-3.11 (m, 2H), 2.27-1.93 (m, 2H), 1.50/1.45 (two overlapping s, 9H), 0.71-0.59 (m, 4H).

1. additionDuring the heating, additional 0.1 eq of V-50 was added to the reaction mixture every 30 minutes
2. additionTotally, 0.7 eq of V-50 was added
3. temperatureAfter heating at 100° C. for 4 hrs
4. customthe reaction mixture was evaporated
5. additiontreated with 2N NaOH
6. extractionIt was extracted with ethyl acetate (2×50 mL)
7. extractionextracted with ethyl acetate (2×50 mL)
8. washThe combined organic layers were washed with water and brine
9. dry with materialdried (Na2SO4)
10. filtrationfiltered
11. customevaporated

ORD record

ord-897f5411a0db424c938e2a2fb5bdba0f

Source dataset

uspto-grants-2015_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08927739B2