Cesium hydroxide → 2'-Hydroxyacetophenone

HRID 1424758Notes

Reaction equation

HRID 1424758 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].[OH-:11].[Cs+]>C(OCC)(=O)C.CCCCCCC>[OH:11][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 62750Cesium hydroxideHCID 750602'-Bromoacetophenone

Product 1

HCID 83752'-HydroxyacetophenoneYield 83%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

Following general operating mode A, 2′-bromoacetophenone (199 mg, 1.0 mmol) was reacted with cesium hydroxide to give the expected product in the form of an oil with a yield of 83% (eluent: ethyl acetate/heptane 20:80).

Sources & evidence

ORD record
ord-d9cf9657d5c74bd2a309b6ae23149e41
Source dataset
uspto-grants-2015_01
Patent number
US08927779B2

Reaction notes

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