3-Bromoanisole → 3-Methoxyphenol

HRID 1424761Notes

Reaction equation

HRID 1424761 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](Br)[CH:6]=[CH:7][CH:8]=1.[OH-:10].[Cs+]>C(OCC)(=O)C.CCCCCCC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:10])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 169713-BromoanisoleHCID 62750Cesium hydroxide

Product 1

HCID 90073-MethoxyphenolYield 85%

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

Following general operating mode B, 3-methoxybromobenzene (127 μL, 1.0 mmol) was reacted with cesium hydroxide to give the expected product in the form of an oil with a yield of 85% (eluent: ethyl acetate/heptane 10:90).

Sources & evidence

ORD record
ord-c637ca45c58945a893f6b7571c382e82
Source dataset
uspto-grants-2015_01
Patent number
US08927779B2

Reaction notes

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