Tetrahydrofuran → [4-(4-Amino-isoquinolin-1-yloxy)-piperidin-1-yl]-(1-methyl-cyclopropyl)-methanone

HRID 142496Notes

Reaction equation

HRID 142496 reaction equation
[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:1][C:2]1([C:5](=[O:6])[N:7]2[CH2:8][CH2:9][CH:10]([O:13][c:14]3[n:15][cH:16][c:17]([N+:24]([O-:25])=[O:26])[c:18]4[cH:19][cH:20][cH:21][cH:22][c:23]34)[CH2:11][CH2:12]2)[CH2:3][CH2:4]1.[H:32][H:33]>>[CH3:1][C:2]1([C:5](=[O:6])[N:7]2[CH2:8][CH2:9][CH:10]([O:13][c:14]3[n:15][cH:16][c:17]([NH2:24])[c:18]4[cH:19][cH:20][cH:21][cH:22][c:23]34)[CH2:11][CH2:12]2)[CH2:3][CH2:4]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 69056099(1-Methyl-cyclopropyl)-[4-(4-nitro-isoquinolin-1-yloxy)-piperidin-1-yl]-methanoneHCID 178418361HCID 178418361, compound

Product 1

HCID 57832814[4-(4-Amino-isoquinolin-1-yloxy)-piperidin-1-yl]-(1-methyl-cyclopropyl)-methanone

Sources & evidence

ORD record
ord-19eb463b8959443ebd65880623a91695
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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