Thionyl Chloride → 4-Chloro-5-ethyl-1H-imidazole-2-carbonyl chloride

HRID 1425013Notes

Reaction equation

HRID 1425013 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([C:9]([OH:11])=O)[NH:5][C:6]=1[CH2:7][CH3:8].S(Cl)([Cl:14])=O>>[Cl:1][C:2]1[N:3]=[C:4]([C:9]([Cl:14])=[O:11])[NH:5][C:6]=1[CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 675489294-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

Product 1

HCID 866485554-Chloro-5-ethyl-1H-imidazole-2-carbonyl chloride

Conditions

Temperature
75 °C

Procedure

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained by the method described in Example (1d) (55 mg, 0.29 mmol) was dissolved in thionyl chloride (1.5 mL), and the mixture was stirred at 75° C. for 50 minutes. The reaction solution was concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customThe resulting compound was used for the next reaction without purification

Sources & evidence

ORD record
ord-dd3f067052344a3f8f5b6f674aa55008
Source dataset
uspto-grants-2015_01
Patent number
US08927588B2

Reaction notes

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