Thionyl Chloride → 4-Chloro-5-ethyl-1H-imidazole-2-carbonyl chloride

Participants

Reaction Conditions

Reaction Steps

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained by the method described in Example (1d) (55 mg, 0.29 mmol) was dissolved in thionyl chloride (1.5 mL), and the mixture was stirred at 75° C. for 50 minutes. The reaction solution was concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

Provenance & Evidence