Methyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate → Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate
반응식
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[C:21]([CH3:24])=[N:22][CH:23]=2)[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[C:21]([CH3:24])=[N:22][CH:23]=2)[CH2:14][C@H:13]1[O:29][CH3:30]참가 물질
3
실험 절차
The same operation as in Example (160c) was performed using methyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate obtained in Example (171a) (225 mg) and a 10% palladium-carbon catalyst (250 mg), to obtain 113 mg of the title compound as a yellow oily substance. The resulting compound was used for the next reaction without purification.
출처 및 근거
- ORD 기록
- ord-0bcb8051249e4661a88823027b3a4050
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08927588B2
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