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Methyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate → Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate | HCID 86648719 | — |
| 触媒 | HCID 178418390 | HCID 178418390 | — |
| 生成物 | Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate | HCID 86648721 | 74.3% |
反応手順
The same operation as in Example (160c) was performed using methyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate obtained in Example (171a) (225 mg) and a 10% palladium-carbon catalyst (250 mg), to obtain 113 mg of the title compound as a yellow oily substance. The resulting compound was used for the next reaction without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08927588B2 |
| 出典データセット | uspto-grants-2015_01 |
| ORD ID | ord-0bcb8051249e4661a88823027b3a4050 |
| 出典メモ | uspto-grants-2015_01 |