反应详情

The same operation as in Example (1i) was performed using ethyl trans-3-{4-[(4-chloro-5-ethyl-1H-imidazole-2-carbonyl)amino]cyclohexyl}benzoate obtained in Example (193b) (43 mg, 0.106 mmol) and lithium hydroxide monohydrate (44 mg, 1.06 mmol), to obtain 23 mg of the title compound as a white solid (58%).