反应详情

Hexadecanedioic acid tert-butyl ester 2,5-dioxo-pyrrolidin-1-yl ester (370 mg, 0.842 mmol) was dissolved in NMP (8 mL), 4 aminomethyl benzoic acid (127.2 mg, 0.842 mmol) was added, the mixture was stirred at room temperature overnight, followed by heating at for 2 hours at 50 degrees celcius. After cooling to room temperature the mixture was poured into water. Product isolated by filtration dried and used for the next step without any further purification.

1. temperatureby heating at for 2 hours at 50 degrees celcius
2. temperatureAfter cooling to room temperature the mixture
3. customProduct isolated by filtration
4. customdried
5. customused for the next step without any further purification