反应详情

温度

30 °C

1.64 g fusidic acid, 313 ml ethanol, 380 ml water, and 162 mg acetone were mixed and the saturated solution was filtered through a filter. 178 g fusidic acid was dissolved in 693 ml ethanol and 25 ml acetone and the solution was filtered through a filter. The first solution was poured into a 5 litre flask and stirred at 180 rpm in a water bath at temperature 30° C. The solution was seeded with 0.45 g fusidic acid hemihydrate having the characteristics as described in example 1. The second solution and water (934 ml) were added to the flask at 7-8 ml/min in parallel, making the total addition time 90 minutes. After completed addition the crystal suspension was stirred for further 30 minutes. The crystals were filtered off, and the crystals were dried at 30° C. for 18 hours under vacuum to give crystalline fusidic acid hemihydrate as described in example 1 exhibiting one or more of the following features x)-y), respectively:

1. filtrationthe saturated solution was filtered through a filter
2. dissolution178 g fusidic acid was dissolved in 693 ml ethanol
3. filtration25 ml acetone and the solution was filtered through a filter
4. additionThe first solution was poured into a 5 litre flask
5. additionThe second solution and water (934 ml) were added to the flask at 7-8 ml/min in parallel
6. customthe total addition time 90 minutes
7. additionaddition the crystal suspension
8. stirringwas stirred for further 30 minutes
9. filtrationThe crystals were filtered off
10. customthe crystals were dried at 30° C. for 18 hours under vacuum