反应详情

温度

80 °C

A mixture of 3,6-dichloro-4-phenylpyridazine (1.35 g, 6 mmol), 1-(2-pyrimidyl)piperazine (1.2 g, 6.0 mmol) in 10 ml of 1-BuOH was heated with stirring at 80° C. for 12 h. The solvent was removed by evaporation in vacuo, the residue was treated with water to give a suspension. The solid was then filtered off, washed with water, dried over filter funnel in vacuo to give white solid (1.8 g, 5.2 mmol, yield 86.0%). ESI-MS: m/z 353.9.

1. temperaturewas heated
2. customThe solvent was removed by evaporation in vacuo
3. additionthe residue was treated with water
4. customto give a suspension
5. filtrationThe solid was then filtered off
6. washwashed with water
7. customdried
8. filtrationover filter funnel in vacuo