1-(2-Pyrimidinyl)piperazine → 2-(4-(6-Chloro-5-phenylpyridazin-3-yl)piperazin-1-yl)pyrimidine

Participants

Reaction Conditions

Reaction Steps

A mixture of 3,6-dichloro-4-phenylpyridazine (1.35 g, 6 mmol), 1-(2-pyrimidyl)piperazine (1.2 g, 6.0 mmol) in 10 ml of 1-BuOH was heated with stirring at 80° C. for 12 h. The solvent was removed by evaporation in vacuo, the residue was treated with water to give a suspension. The solid was then filtered off, washed with water, dried over filter funnel in vacuo to give white solid (1.8 g, 5.2 mmol, yield 86.0%). ESI-MS: m/z 353.9.

Provenance & Evidence