HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(5-Methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-(5-Methoxy-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one | HCID 86695553 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(5-Methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one | HCID 86695554 | — |
Reaction Steps
A solution of 5-(5-methoxy-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (500 mg, 1.58 mmol) in a mixture of MeOH (5 mL) and concentrated aqueous HCl (0.65 mL) is heated at reflux for 2 h. Most of the volatiles are removed under reduced pressure and water is added. The formed precipitate is filtered off and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933079B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-1f793271f44e4fdea3b4d62ec216d32b |
| Source note | uspto-grants-2015_01 |