Hydrochloric Acid → 5-(5-Methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

HRID 1425753Notes

Reaction equation

HRID 1425753 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][O:10][C:11]2[CH:16]=[N:15][N:14](C3CCCCO3)[C:13](=[O:23])[CH:12]=2)=[N:7][CH:8]=1.Cl>CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][O:10][C:11]2[CH:16]=[N:15][NH:14][C:13](=[O:23])[CH:12]=2)=[N:7][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 866955535-(5-Methoxy-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one

Product 1

HCID 866955545-(5-Methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5-(5-methoxy-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one (500 mg, 1.58 mmol) in a mixture of MeOH (5 mL) and concentrated aqueous HCl (0.65 mL) is heated at reflux for 2 h. Most of the volatiles are removed under reduced pressure and water is added. The formed precipitate is filtered off and dried.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 2 h
  3. customMost of the volatiles are removed under reduced pressure and water
  4. additionis added
  5. filtrationThe formed precipitate is filtered off
  6. customdried

Sources & evidence

ORD record
ord-1f793271f44e4fdea3b4d62ec216d32b
Source dataset
uspto-grants-2015_01
Patent number
US08933079B2

Reaction notes

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