4-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one → 2-[2-(4-Hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

HRID 1425754Notes

Reaction equation

HRID 1425754 reaction equation
C(OC1C=CN([CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][OH:25])=[CH:20][C:19]=2[CH3:26])=[O:17])C(=O)C=1)C1C=CC=CC=1.[CH3:28][O:29][C:30]1[CH:31]=[CH:32][C:33]([CH2:36][O:37][C:38]2[CH:43]=[N:42][NH:41][C:40](=[O:44])[CH:39]=2)=[N:34][CH:35]=1>>[OH:25][CH2:24][C:21]1[CH:22]=[CH:23][C:18]([C:16](=[O:17])[CH2:15][N:41]2[C:40](=[O:44])[CH:39]=[C:38]([O:37][CH2:36][C:33]3[CH:32]=[CH:31][C:30]([O:29][CH3:28])=[CH:35][N:34]=3)[CH:43]=[N:42]2)=[C:19]([CH3:26])[CH:20]=1

Participants

3

Reactant 2

HCID 866955374-Benzyloxy-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-oneHCID 866955545-(5-Methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one

Product 1

HCID 866955552-[2-(4-Hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-oneYield 70%

Procedure

2-[2-(4-Hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one is prepared following preparation 1c employing 5-(5-methoxy-pyridin-2-ylmethoxy)-2H-pyridazin-3-one (preparation 9b) instead of 4-benzyloxy-1H-pyridin-2-one.

Sources & evidence

ORD record
ord-e4c78fe162fb44d6a5ccffe41da8200d
Source dataset
uspto-grants-2015_01
Patent number
US08933079B2

Reaction notes

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