1,4-Dioxane → 3-[2-[4-[5-Phenyl-4-[(2,2,2-trifluoroethoxy)methyl]oxazol-2-yl]piperidino]ethyl]-6-methoxybenzenesulfonamide

HRID 142577Notes

Reaction equation

HRID 142577 reaction equation
[CH:40]([N:41]([CH2:42][CH3:43])[CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[Cl:25][CH2:26][CH2:27][c:28]1[cH:29][cH:30][c:31]([O:38][CH3:39])[c:32]([S:34](=[O:35])(=[O:36])[NH2:37])[cH:33]1.[O:49]1[CH2:50][CH2:51][O:52][CH2:53][CH2:54]1.[c:1]1(-[c:7]2[c:8]([CH2:18][O:19][CH2:20][C:21]([F:22])([F:23])[F:24])[n:9][c:10]([CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[o:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1(-[c:7]2[c:8]([CH2:18][O:19][CH2:20][C:21]([F:22])([F:23])[F:24])[n:9][c:10]([CH:12]3[CH2:13][CH2:14][N:15]([CH2:26][CH2:27][c:28]4[cH:29][cH:30][c:31]([O:38][CH3:39])[c:32]([S:34](=[O:35])(=[O:36])[NH2:37])[cH:33]4)[CH2:16][CH2:17]3)[o:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

5

Reactant 4

HCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 187004435-(2-Chloroethyl)-2-methoxy-benzenesulfonamideHCID 187004502-(4-Piperidinyl)-4-(2,2,2-trifluoroethoxymethyl)-5-phenyloxazole

Product 1

HCID 187004673-[2-[4-[5-Phenyl-4-[(2,2,2-trifluoroethoxy)methyl]oxazol-2-yl]piperidino]ethyl]-6-methoxybenzenesulfonamide

Sources & evidence

ORD record
ord-47e47dacf07c45428ebfd694bc04379d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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