反应详情

To a solution of D-Ser-OMe (LXXXVIII) in dry DCM was added TEA (1.2 eq). After the solution became clear, trityl chloride (1 eq in dry DCM) was added dropwise and stirred for 2 hours. The reaction mixture was washed with 2M HCl, brine and dried over anhydrous MgSO4. The solvent was removed under reduced pressure to give the crude product as a colorless oil. The oil crystallized from Et2O/hexane to produce pure (R)-methyl 3-hydroxy-2-(tritylamino)propanoate (LXXXIX) as white solid (85% yield).

1. washThe reaction mixture was washed with 2M HCl, brine
2. dry with materialdried over anhydrous MgSO4
3. customThe solvent was removed under reduced pressure
4. customto give the crude product as a colorless oil
5. customThe oil crystallized from Et2O/hexane