1,2-Dibromoethane → 1-(6-Chloropyridin-3-yl)cyclopropane-1-carbonitrile

HRID 1425968Notes

Reaction equation

HRID 1425968 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.Br[CH2:12][CH2:13]Br>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([C:9]#[N:10])[CH2:13][CH2:12]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 78391,2-DibromoethaneHCID 14751282-(6-Chloropyridin-3-yl)acetonitrile

Product 1

HCID 221593571-(6-Chloropyridin-3-yl)cyclopropane-1-carbonitrileYield 43%

Procedure

The title compound was prepared from (6-chloro-pyridin-3-yl)-acetonitrile and 1,2-dibromoethane following a procedure analogous to that described in Step 3 for Intermediate 4. Yield: 43% of theory; LC (method 3): tR=2.71 min; Mass spectrum (ESI+): m/z=179/181 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-95b352639e8a465aad9489a99bdc1de6
Source dataset
uspto-grants-2015_01
Patent number
US08933072B2

Reaction notes

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