4-Bromo-2-hydroxypyridine → 1,1-Dimethylethyl 3-(4-bromo-2-oxo-1(2H)-pyridinyl)-1-azetidinecarboxylate

HRID 1425980Notes

Reaction equation

HRID 1425980 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.[C:9]([O:13][C:14]([N:16]1[CH2:19][CH:18](I)[CH2:17]1)=[O:15])([CH3:12])([CH3:11])[CH3:10]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:18]2[CH2:17][N:16]([C:14]([O:13][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:15])[CH2:19]2)[C:4](=[O:8])[CH:3]=1

Participants

3

Reactant 2

HCID 8171154-Bromo-2-hydroxypyridineHCID 11000522Tert-butyl 3-iodoazetidine-1-carboxylate

Product 1

HCID 706517501,1-Dimethylethyl 3-(4-bromo-2-oxo-1(2H)-pyridinyl)-1-azetidinecarboxylate

Procedure

The title compound was prepared from 4-bromopyridin-2(1H)-one and 3-iodo-azetidine-1-carboxylic acid tert-butyl ester following a procedure analogous to that described for Intermediate 22.

Sources & evidence

ORD record
ord-7c15b827f7224a02a25cfd224d3547bd
Source dataset
uspto-grants-2015_01
Patent number
US08933072B2

Reaction notes

Loading…