(alphaS)-4-Bromo-alpha-methylbenzenemethanamine → HCID 67997823, compound

HRID 1426002Notes

Reaction equation

HRID 1426002 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH2:10])[CH3:9])=[CH:4][CH:3]=1.[CH:11]1([CH2:14][C:15](=[O:18])[CH:16]=[CH2:17])[CH2:13][CH2:12]1>CO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH:11]2[CH2:13][CH2:12]2)[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 852999(alphaS)-4-Bromo-alpha-methylbenzenemethanamineHCID 666525031352754-33-6

Product 1

HCID 67997823HCID 67997823, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

(S)-1-(4-Bromophenyl)ethanamine (3.33 g) was added to a solution of 1-cyclopropylbut-3-en-2-one (3.07 g) in methanol (10 mL). The mixture was heated to 80° C. and stirred at this temperature for 10 min. After cooling to room temperature, the mixture was concentrated to give the crude title compound which was used without further purification. Yield: 5.20 g (crude).

Workup

  1. temperatureAfter cooling to room temperature
  2. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-d8d93aabaa8f49b4bf5f1b1660e50c36
Source dataset
uspto-grants-2015_01
Patent number
US08933072B2

Reaction notes

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