4-Bromo-1-(oxan-4-yl)-1H-pyrazole → (S)-6-(2-Hydroxy-2-methyl-propyl)-6-phenyl-3-((S)-1-{4-[1-(tetrahydro-Pyran-4-yl)-1H-pyrazol-4-yl]-phenyl}-ethyl)-[1,3]oxazinan-2-one

Participants

Reaction Steps

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-{(S)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-ethyl}-1,3-oxazinan-2-one and 4-bromo-1-(tetrahydro-pyran-4-yl)-1H-pyrazole following a procedure analogous to that described in Example 1. Yield: 18% of theory; LC (method 3): tR=2.98 min; Mass spectrum (ESI+): m/z=504 [M+H]+.

Provenance & Evidence