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HRID1426022

反应详情

EQUATION

反应方程式

HRID 1426022 的结构方程式

REACTANTS

反应物

2
反应SMILES：N#CC1(c2ccc(Cl)nc2)CC1
HCID22159357

1-(6-Chloropyridin-3-yl)cyclopropane-1-carbonitrile

C9H7ClN2

反应SMILES：C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O
HCID59532385

(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one

C28H38BNO5

PRODUCTS

产物

1
反应SMILES：C[C@@H](c1ccc(-c2ccc(C3(C#N)CC3)cn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O
HCID70651286

未命名化合物

收率 48%

PROCEDURE

实验过程

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-{(S)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-ethyl}-1,3-oxazinan-2-one and 1-(6-chloro-pyridin-3-yl)-cyclopropanecarbonitrile following a procedure analogous to that described in Example 1. Yield: 48% of theory; LC (method 3): tR=3.52 min; Mass spectrum (ESI+): m/z=496 [M+H]+.