1-(6-Chloropyridin-3-yl)cyclopropane-1-carbonitrile → HCID 70651286, compound

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Reaction Steps

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-{(S)-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-ethyl}-1,3-oxazinan-2-one and 1-(6-chloro-pyridin-3-yl)-cyclopropanecarbonitrile following a procedure analogous to that described in Example 1. Yield: 48% of theory; LC (method 3): tR=3.52 min; Mass spectrum (ESI+): m/z=496 [M+H]+.

Provenance & Evidence