4-(Methylthio)aniline → HCID 85984633, compound

HRID 1426076Notes

Reaction equation

HRID 1426076 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([Cl:10])[N:5]=[CH:4][N:3]=1.[CH3:11][S:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1>>[Cl:10][C:6]1[C:7]([C:8]#[N:9])=[C:2]([NH:19][C:16]2[CH:17]=[CH:18][C:13]([S:12][CH3:11])=[CH:14][CH:15]=2)[N:3]=[CH:4][N:5]=1

Participants

3

Reactant 2

HCID 660384-(Methylthio)anilineHCID 5993714,6-Dichloropyrimidine-5-carbonitrile

Product 1

HCID 85984633HCID 85984633, compound

Procedure

Intermediate 4-chloro-6-(4-methylsulfanyl-phenylamino)-pyrimidine-5-carbonitrile was prepared in a similar manner as described herein using 4,6-dichloro-pyrimidine-5-carbonitrile and 4-methylsulfanyl-phenylamine. 1H-NMR (DMSO-d6): 10.22 (1H, s), 8.53 (1H, s) 7.43 (2H, m), 7.40 (2H, m), 2.49 (3H, s) ppm. LCMS: 277.0, 234.0, 149.0.

Sources & evidence

ORD record
ord-479b761fbcc14a9c928e9511431f219e
Source dataset
uspto-grants-2015_01
Patent number
US08933083B2

Reaction notes

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