反应详情

Following the method of Example 1, Step C, 1-benzoyl-3-(3-(benzyloxy)-5-bromopyrazin-2-yl)thiourea (2.38 g, 5.37 mmol), and potassium carbonate (890 mg, 6.44 mmol) were reacted in ethanol (30 mL) to provide 1-(3-(benzyloxy)-5-bromopyrazin-2-yl)thiourea (1.82 g, 53%) as a light gray powder. 1H NMR (d6-DMSO) δ 9.62 (bs, 1H), 9.37 (bs, 1H), 8.73 (bs, 1H), 8.03 (s, 1H), 7.55 (d, 2H), 7.38-7.45 (m, 3H), 5.43 (s, 2H).