反应详情

2-(4-Methylthiazol-2-ylamino)pyridin-3-ol (prepared according to Example 3, Step A; 200 mg, 0.96 mmol), 2-(chloromethyl)thiophene (160 mg, 0.96 mmol) and potassium carbonate (333 mg, 2.4 mmol) were reacted according to Example 3, Step B, to provide the title compound (47 mg, 14% yield) as a tan solid. 1H NMR (d6-DMSO) δ 10.90 (bs, 1H), 7.98 (m, 1H), 7.69 (m, 1H), 7.59 (m, 1H), 7.35 (m, 1H), 7.12 (m, 1H), 7.06 (m, 1H), 6.83 (s, 1H), 5.52 (s, 2H), 2.31 (s, 3H). Mass spectrum (apci) m/z=304 (M+H-HCl).