Trimethylsilylacetylene → 2-tert-Butyl-6-trimethylsilanylethynyl-pyrazolo[1,5-a]pyrimidine

HRID 1426207Notes

Reaction equation

Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=2)[CH:7]=1.[CH3:15][Si:16]([C:19]#[CH:20])([CH3:18])[CH3:17]>>[C:11]([C:9]1[CH:10]=[C:5]2[N:4]=[CH:3][C:2]([C:20]#[C:19][Si:16]([CH3:18])([CH3:17])[CH3:15])=[CH:7][N:6]2[N:8]=1)([CH3:14])([CH3:13])[CH3:12]

Participants

Reactant 2

HCID 66111Trimethylsilylacetylene

HCID 583166976-Bromo-2-tert-butylpyrazolo[1,5-a]pyrimidine

Product 1

HCID 583167152-tert-Butyl-6-trimethylsilanylethynyl-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, brown solid, MS: m/e=272.3 (M++H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-tert-butyl-pyrazolo[1,5-a]pyrimidine (example 9, step 1) and trimethylsilylacetylene.

Sources & evidence

ORD record: ord-de7b51e52a0c435b890abd814d556842
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08933094B2

Reaction notes

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