2-Chloro-5-iodopyridine → 2-tert-Butyl-6-(6-chloro-pyridin-3-ylethynyl)-pyrazolo[1,5-a]pyrimidine

HRID 1426209Notes

Reaction equation

HRID 1426209 reaction equation
[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[CH:14])=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:16][C:17]1[CH:22]=[CH:21][C:20](I)=[CH:19][N:18]=1>>[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:20]3[CH:19]=[N:18][C:17]([Cl:16])=[CH:22][CH:21]=3)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 43971762-Chloro-5-iodopyridineHCID 583167022-tert-Butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 532473282-tert-Butyl-6-(6-chloro-pyridin-3-ylethynyl)-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, light yellow solid, MS: m/e=311.3 (M+H+), can be prepared in accordance with the general method of example 1 from 2-tert-butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine (example 21, step 2) and 2-chloro-5-iodopyridine.

Sources & evidence

ORD record
ord-9f758becac544722905bbc2d2824b917
Source dataset
uspto-grants-2015_01
Patent number
US08933094B2

Reaction notes

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