3-Bromo-5-chloropyridine → 2-tert-Butyl-6-(5-chloro-pyridin-3-ylethynyl)-pyrazolo[1,5-a]pyrimidine

HRID 1426211Notes

Reaction equation

HRID 1426211 reaction equation
[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[CH:14])=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:17]1[CH:18]=[N:19][CH:20]=[C:21]([Cl:23])[CH:22]=1>>[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:17]3[CH:18]=[N:19][CH:20]=[C:21]([Cl:23])[CH:22]=3)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 6062563-Bromo-5-chloropyridineHCID 583167022-tert-Butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 532473302-tert-Butyl-6-(5-chloro-pyridin-3-ylethynyl)-pyrazolo[1,5-a]pyrimidine

Procedure

The title compound, light yellow solid, MS: m/e=311.2 (M+H+), can be prepared in accordance with the general method of example 1 from 2-tert-butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine (example 21, step 2) and 3-bromo-5-chloropyridine.

Sources & evidence

ORD record
ord-0a11cc1525174165b8a5a46efe514731
Source dataset
uspto-grants-2015_01
Patent number
US08933094B2

Reaction notes

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