1-Ethynyl-3-fluorobenzene → 2-tert-Butyl-6-(3-fluoro-phenylethynyl)-[1,2,4]triazolo[1,5-a]pyrimidine

HRID 1426245Notes

Reaction equation

HRID 1426245 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[N:6]([N:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[N:10]=2)[CH:7]=1.[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=1)#[CH:16]>>[C:11]([C:9]1[N:10]=[C:5]2[N:4]=[CH:3][C:2]([C:16]#[C:15][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)=[CH:7][N:6]2[N:8]=1)([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 5202181-Ethynyl-3-fluorobenzeneHCID 583167046-Bromo-2-tert-butyl-[1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 532475732-tert-Butyl-6-(3-fluoro-phenylethynyl)-[1,2,4]triazolo[1,5-a]pyrimidine

Procedure

The title compound, a light yellow solid, MS: m/e=295.2 (M+H+), can be prepared in accordance with the general method of example 1 from 6-bromo-2-tert-butyl-[1,2,4]triazolo[1,5-a]pyrimidine (example 42, step 1) and ethynyl-3-fluorobenzene.

Sources & evidence

ORD record
ord-ab0ba6b0468149d198d1eb64f7689a18
Source dataset
uspto-grants-2015_01
Patent number
US08933094B2

Reaction notes

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