2-tert-Butyl-6-trimethylsilanylethynyl-[1,2,4]triazolo[1,5-a]pyrimidine → 2-tert-Butyl-6-(3,4-difluoro-phenylethynyl)-[1,2,4]triazolo[1,5-a]pyrimidine

HRID 1426246Notes

Reaction equation

HRID 1426246 reaction equation
[C:1]([C:5]1[N:19]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][Si](C)(C)C)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:20][CH:21]1[C:26]([F:28])(I)[CH:25]=[CH:24][CH:23]=[CH:22]1>>[C:1]([C:5]1[N:19]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:24]3[CH:23]=[CH:22][C:21]([F:20])=[C:26]([F:28])[CH:25]=3)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 583166982-tert-Butyl-6-trimethylsilanylethynyl-[1,2,4]triazolo[1,5-a]pyrimidineHCID 672389423,4-Difluoro-4-iodobenzene

Product 1

HCID 532475742-tert-Butyl-6-(3,4-difluoro-phenylethynyl)-[1,2,4]triazolo[1,5-a]pyrimidine

Procedure

The title compound, a light yellow solid, MS: m/e=313.1 (M+H+), can be prepared in accordance with the general method of example 43, step 2 from 2-tert-butyl-6-trimethylsilanylethynyl-[1,2,4]triazolo[1,5-a]pyrimidine (example 43, step 1) and 3,4-difluoro-4-iodobenzene.

Sources & evidence

ORD record
ord-94f1369afed14acfa57912876410bda2
Source dataset
uspto-grants-2015_01
Patent number
US08933094B2

Reaction notes

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