Hydrochloric Acid → HCID 53419611, compound

HRID 1426349Notes

Reaction equation

HRID 1426349 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([OH:7])=[O:6].Cl.O1CCOC[CH2:17]1>CO>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:12])([F:13])[F:14])[CH:10]=1)[C:5]([O:7][CH3:17])=[O:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 27831463-hydroxy-5-(trifluoromethyl)benzoic Acid

Product 1

HCID 53419611HCID 53419611, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-hydroxy-5-(trifluoromethyl)benzoic acid (3.56 g, 17.3 mmol) in methanol (110 mL) was added 4.0M hydrogen chloride in dioxane (110 mL, 460 mmol). The resulting mixture was stirred at room temperature overnight. The solvent was concentrated. The residue was purified by flash chromatography on a silica gel column to give the desired product as white solid.

Workup

  1. concentrationThe solvent was concentrated
  2. customThe residue was purified by flash chromatography on a silica gel column

Sources & evidence

ORD record
ord-bbeb143881784345a084efe8ee837d1c
Source dataset
uspto-grants-2015_01
Patent number
US08933085B2

Reaction notes

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