3-Hydroxyazetidine → tert-Butyl 4-{[6-[(3-hydroxyazetidin-1-yl)methyl]-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate

HRID 1426358Notes

Reaction equation

HRID 1426358 reaction equation
[CH:1]([C:3]1[N:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:6]=[C:5]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]2)[CH:4]=1)=O.[NH:27]1[CH2:30][CH:29]([OH:31])[CH2:28]1>>[OH:31][CH:29]1[CH2:30][N:27]([CH2:1][C:3]2[N:8]=[C:7]([C:9]([F:11])([F:10])[F:12])[N:6]=[C:5]([O:13][CH:14]3[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]3)[CH:4]=2)[CH2:28]1

Participants

3

Reactant 2

HCID 15142903-HydroxyazetidineHCID 86666511tert-Butyl 4-{[6-formyl-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate

Product 1

HCID 69673616tert-Butyl 4-{[6-[(3-hydroxyazetidin-1-yl)methyl]-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate

Procedure

This compound was prepared according to the method of Example 41, Step 2 using tert-butyl 4-{[6-formyl-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate and azetidin-3-ol as starting materials. LCMS (M+H)+: 433.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-a174d4a6262943a4b10d001d42bc286d
Source dataset
uspto-grants-2015_01
Patent number
US08933085B2

Reaction notes

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