HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxyazetidine → tert-Butyl 4-{[6-[(3-hydroxyazetidin-1-yl)methyl]-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxyazetidine | HCID 1514290 | — |
| Reactant | tert-Butyl 4-{[6-formyl-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate | HCID 86666511 | — |
| Product | tert-Butyl 4-{[6-[(3-hydroxyazetidin-1-yl)methyl]-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate | HCID 69673616 | — |
Reaction Steps
This compound was prepared according to the method of Example 41, Step 2 using tert-butyl 4-{[6-formyl-2-(trifluoromethyl)pyrimidin-4-yl]oxy}piperidine-1-carboxylate and azetidin-3-ol as starting materials. LCMS (M+H)+: 433.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08933085B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-a174d4a6262943a4b10d001d42bc286d |
| Source note | uspto-grants-2015_01 |