反应详情

温度

120 °C

A mixture of 2-chloro-5-trifluoromethyl-[1,3,4]thiadiazole (0.70 g, 3.72 mmol) (prepared by a procedure similar to that described in DE 82/3218482), 4-methylamino-piperidine-1-carboxylic acid benzyl ester hydrochloride (1.06 g, 3.72 mmol) and diisopropylethylamine (1.60 ml, 9.30 mmol) in acetonitrile (10 ml) was stirred at 120° C. for 30 min., under microwave irradiation. After cooling to room temperature, the reaction mixture was diluted with dichloromethane and extracted with a 10% solution of ammonium chloride (25 ml). The organic layer was separated, dried (Na2SO4) and the solvent evaporated in vacuo. The crude product was purified by short open column chromatography (silica gel; 0-0.5% ammonia in methanol (7M)/dichloromethane). The desired fractions were collected and evaporated in vacuo to yield D1 (0.91 g, 62%) as a solid. C17H19F3N4O2S requires 400. Found 401 (MH+).

1. customprepared by a procedure similar to
2. temperatureAfter cooling to room temperature
3. extractionextracted with a 10% solution of ammonium chloride (25 ml)
4. customThe organic layer was separated
5. dry with materialdried (Na2SO4)
6. customthe solvent evaporated in vacuo
7. customThe crude product was purified by short open column chromatography (silica gel; 0-0.5% ammonia in methanol (7M)/dichloromethane)
8. customThe desired fractions were collected
9. customevaporated in vacuo