Tert-butyl 4-(2H-tetrazol-5-YL)piperidine-1-carboxylate → HCID 178420016, compound

HRID 1426398Notes

Reaction equation

HRID 1426398 reaction equation
[NH:1]1[C:5]([CH:6]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)=[N:4][N:3]=[N:2]1>Cl.O1CCOCC1>[NH:4]1[C:5]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)=[N:1][N:2]=[N:3]1

Participants

4

Reactant 1

HCID 18187701Tert-butyl 4-(2H-tetrazol-5-YL)piperidine-1-carboxylate

Product 1

HCID 178420016HCID 178420016, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The title compound from Step A above (197 mg, 0.77 mmol) was dissolved in 4 M HCl in dioxane (3.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-32) (116 mg, 98%). ESI-MS calculated for C6H11N5: Exact Mass: 153.13. Found 154.12.

Workup

  1. concentrationThe product was concentrated under reduced pressure
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-ccda3c0c1e9e440493caec890ddd5700
Source dataset
uspto-grants-2015_01
Patent number
US08933102B2

Reaction notes

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