Hydrochloric Acid → HCID 136333945, compound

HRID 1426465Notes

Reaction equation

HRID 1426465 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7]([NH2:9])=[O:8])=[C:4]([NH:10][C:11](=O)[CH2:12][CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:3]=1.[OH-].[Na+].C(O)C.Cl>O>[Br:1][C:2]1[S:6][C:5]2[C:7](=[O:8])[NH:9][C:11]([CH2:12][CH:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)=[N:10][C:4]=2[CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 71147199HCID 71147199, compound

Product 1

HCID 136333945HCID 136333945, compoundYield 60.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

To 5-bromo-3-[(cyclopentylacetyl)amino]thiophene-2-carboxamide (290 mg) were added 2M aqueous sodium hydroxide solution (1.75 mL) and ethanol (3.0 mL), and the mixture was stirred at 70° C. for 2 hr. The reaction system was neutralized with 1M hydrochloric acid at 0° C. Water (2 mL) was added, and the precipitate was collected by filtration to give the title compound (165 mg) as a white solid.

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-2d09b2a31065495197895c36de433297
Source dataset
uspto-grants-2015_01
Patent number
US08933069B2

Reaction notes

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