2,5-Difluorobenzenesulfonyl chloride → HCID 67396338, compound

HRID 1426679Notes

Reaction equation

HRID 1426679 reaction equation
[F:1][C:2]1[C:7]([C:8]2[NH:12][CH:11]=[C:10]([CH2:13][N:14]([CH3:22])[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[F:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=1[S:31](Cl)(=[O:33])=[O:32]>>[F:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=1[S:31]([N:12]1[C:8]([C:7]2[C:2]([F:1])=[N:3][CH:4]=[CH:5][CH:6]=2)=[CH:9][C:10]([CH2:13][N:14]([CH3:22])[C:15](=[O:21])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[CH:11]1)(=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 67396538HCID 67396538, compound

Product 1

HCID 67396338HCID 67396338, compound

Procedure

By an operation similar to that in Reference Example 32 and using tert-butyl {[5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}methylcarbamate (305 mg), and 2,5-difluorobenzenesulfonyl chloride (319 mg), the title compound was obtained as a colorless oil (yield 160 mg, 33%).

Sources & evidence

ORD record
ord-7838a570e8ef4836a7712f9081409c15
Source dataset
uspto-grants-2015_01
Patent number
US08933105B2

Reaction notes

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