HCID 67395969, compound → HCID 67396275, compound

HRID 1426717Notes

Reaction equation

HRID 1426717 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:10][C:11]1[C:12]([F:42])=[C:13]([C:35]2[C:36]([F:41])=[N:37][CH:38]=[CH:39][CH:40]=2)[N:14]([S:16]([C:19]2[CH:20]=[C:21]([CH:32]=[CH:33][CH:34]=2)[C:22]([O:24]CC2C=CC=CC=2)=[O:23])(=[O:18])=[O:17])[CH:15]=1)[CH3:9])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[C:1]([O:5][C:6]([N:8]([CH2:10][C:11]1[C:12]([F:42])=[C:13]([C:35]2[C:36]([F:41])=[N:37][CH:38]=[CH:39][CH:40]=2)[N:14]([S:16]([C:19]2[CH:20]=[C:21]([CH:32]=[CH:33][CH:34]=2)[C:22]([OH:24])=[O:23])(=[O:18])=[O:17])[CH:15]=1)[CH3:9])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 67395969HCID 67395969, compound

Product 1

HCID 67396275HCID 67396275, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of benzyl 3-{[4-{[(tert-butoxycarbonyl)(methyl)amino]methyl}-3-fluoro-2-(2-fluoropyridin-3-yl)-1H-pyrrol-1-yl]sulfonyl}benzoate (1.03 g) in ethanol (5 mL) was added 10% palladium carbon (50% containing water, 200 mg), and the mixture was stirred for 1 hr under a hydrogen atmosphere. The reaction mixture was filtrated, and concentrated under reduced pressure to give the title compound as a colorless solid (yield 866 mg, 99%).

Workup

  1. filtrationThe reaction mixture was filtrated
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-892ec4f4e8ee4318b87ac95b79268e6f
Source dataset
uspto-grants-2015_01
Patent number
US08933105B2

Reaction notes

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