反应详情

温度

-35 °C

Under a nitrogen atmosphere, a solution of tert-butyllithium (481 ml, 737.6 mmol, 1.6 M) was added dropwise to a solution of (3-tert-Butoxy-5-fluoro-phenyl)thiocarbamic acid O-isopropyl ester (200 g, 700.83 mmol) in 2-Me-THF (1600 ml) at temperature below −65° C. The reaction temperature was warmed to −35° C., and a second portion of tert-butyllithium (388 ml, 737.6 mmol, 1.9 M) was added slowly while keeping the temperature below −35° C. The reaction mixture was then stirred at this temperature for 3 h and cooled down to −70° C. A solution of N-methyl-N-methoxy chloroacetamide (96.4 g, 700.83 mmol) in 2-MeTHF (300 ml) was added to the reaction mixture while keeping the temperature below −70° C. The mixture was then warmed to −30° C. and stirred for 45 minutes. The cold reaction mixture was quenched by dropwise addition of 30% HCl in isopropanol (240 g) followed by the addition of 1500 ml water. The organic layer was washed sequentially with 1000 ml water, 1500 ml saturated aqueous NaHCO3 and 1500 ml brine. After concentration, the resulting light brown residue was added to isopropanol (135 ml). The mixture was warmed to 50° C. and cooled down slowly to 25° C. n-heptane (135 ml) was added dropwise to the solution and the mixture was stirred overnight. The slurry was filtered and the filter cake was washed with n-heptane (40 ml) followed by another portion of n-heptane (20 ml). The cake was dried under vacuum to yield 1-(5-tert-butoxy-2-isopropoxy-benzothiazol-7-yl)-2-chloro-ethanone as off-white powder (42.8 g, 17.9% yield).

1. customthe temperature below −35° C
2. temperaturecooled down to −70° C
3. customthe temperature below −70° C
4. temperatureThe mixture was then warmed to −30° C.
5. stirringstirred for 45 minutes
6. customThe cold reaction mixture
7. customwas quenched by dropwise addition of 30% HCl in isopropanol (240 g)
8. additionfollowed by the addition of 1500 ml water
9. washThe organic layer was washed sequentially with 1000 ml water, 1500 ml saturated aqueous NaHCO3 and 1500 ml brine
10. concentrationAfter concentration
11. additionthe resulting light brown residue was added to isopropanol (135 ml)
12. temperatureThe mixture was warmed to 50° C.
13. temperaturecooled down slowly to 25° C. n-heptane (135 ml)
14. additionwas added dropwise to the solution
15. stirringthe mixture was stirred overnight
16. filtrationThe slurry was filtered
17. washthe filter cake was washed with n-heptane (40 ml)
18. customThe cake was dried under vacuum