反应详情

温度

60 °C

Commercially available 2-amino-4-chloropyridine (50 g, 389 mmol) was dissolved in acetic anhydride (500 mL), triethylamine (271 mL, 1.94 mol) was added at 20° C., and the mixture was stirred at 60° C. for 12 hours. The mixture was cooled to 25° C. and then the solvent was evaporated. The residue was purified with silica gel column chromatography (n-heptane:ethyl acetate=4:1-1:1) and then the target fraction was concentrated under vacuum to obtain the title compound (66 g, 99%).

1. temperatureThe mixture was cooled to 25° C.
2. customthe solvent was evaporated
3. customThe residue was purified with silica gel column chromatography (n-heptane:ethyl acetate=4:1-1:1)
4. concentrationthe target fraction was concentrated under vacuum