反应详情

温度

140 °C

A mixture of 4-(1-acetylpiperidin-4-yl)benzoic acid described in Production Example 1-10 (4.50 g, 18.2 mmol) and 5 M hydrochloric acid (50 mL, 250 mmol) was stirred under nitrogen atmosphere at 140° C. for 18 hours. The mixture was cooled to room temperature and then the product was collected by filteration and washed with water to obtain the title compound (3.77 g, 86%).

1. temperatureThe mixture was cooled to room temperature
2. customthe product was collected by filteration
3. washwashed with water