Hydrochloric Acid → 4-(Piperidin-4-yl)benzoic acid--hydrogen chloride (1/1)

HRID 1426998Notes

Reaction equation

HRID 1426998 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:19]>>[ClH:19].[NH:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 186177774-(1-Acetylpiperidin-4-yl)benzoic acid

Product 1

HCID 193817644-(Piperidin-4-yl)benzoic acid--hydrogen chloride (1/1)Yield 86%

Conditions

Temperature
140 °C

Procedure

A mixture of 4-(1-acetylpiperidin-4-yl)benzoic acid described in Production Example 1-10 (4.50 g, 18.2 mmol) and 5 M hydrochloric acid (50 mL, 250 mmol) was stirred under nitrogen atmosphere at 140° C. for 18 hours. The mixture was cooled to room temperature and then the product was collected by filteration and washed with water to obtain the title compound (3.77 g, 86%).

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. customthe product was collected by filteration
  3. washwashed with water

Sources & evidence

ORD record
ord-c53fa99c7612466ab8fdc54b20c1b9f4
Source dataset
uspto-grants-2015_01
Patent number
US08933099B2

Reaction notes

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