反应详情

A 2 M sodium hydroxide solution (20 mL) was added to a solution of methyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)nicotinate described in Production Example 28-2 (1.07 g, 3.32 mmol) in ethanol (5 mL), and the mixture was stirred for 1 hour. 2 M hydrochloric acid was added to the reaction liquid at 0° C. The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with a saturated saline solution and then dried over anhydrous sodium sulfate. The drying agent was separated by filtration and then the filtrate was concentrated under vacuum to obtain the title compound (534 mg, 52%).

1. extractionThe aqueous layer was extracted with ethyl acetate
2. washThe combined organic layer was washed with a saturated saline solution
3. dry with materialdried over anhydrous sodium sulfate
4. customThe drying agent was separated by filtration
5. concentrationthe filtrate was concentrated under vacuum