反应详情

温度

120 °C

To a solution of methyl 3-[(5-bromo-2-fluoro-benzoyl)amino]-2,4-dimethyl-benzoate (0.7 g, 1.84 mmol), tert-butyl-dimethyl-(3-piperidylmethoxy)silane (2.53 g, 11.03 mmol, see preparation 14) and Cs2CO3 (1.81 g, 5.50 mmol) in 1,4-dioxane (15 ml) is added Pd2(dba)3 (0.168 g, 0.184 mol) followed by S-Phos (0.075 g, 0.184 mol). The reaction mixture is purged with nitrogen for 5 minutes and then heated at 120° C. After 6 hours, the reaction mixture is concentrated under reduced pressure and residue is carried forward without further purification.

1. customThe reaction mixture is purged with nitrogen for 5 minutes
2. concentrationthe reaction mixture is concentrated under reduced pressure and residue
3. customis carried forward without further purification