Hydrochloride methanol → 1-(3-(4-chlorophenyl)-1,1,1-trifluoropentan-3-yl)-1H-indazol-4-amine

HRID 1427283Notes

Reaction equation

HRID 1427283 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:16]2[C:24]3[C:19](=[C:20]([NH:25]C(=O)OC(C)(C)C)[CH:21]=[CH:22][CH:23]=3)[CH:18]=[N:17]2)([CH2:14][CH3:15])[CH2:9][C:10]([F:13])([F:12])[F:11])=[CH:4][CH:3]=1.Cl.CO>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:16]2[C:24]3[CH:23]=[CH:22][CH:21]=[C:20]([NH2:25])[C:19]=3[CH:18]=[N:17]2)([CH2:14][CH3:15])[CH2:9][C:10]([F:13])([F:11])[F:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 70586827tert-butyl 1-(3-(4-chlorophenyl)-1,1,1-trifluoropentan-3-yl)-1H-indazol-4-ylcarbamate

Product 1

HCID 705766821-(3-(4-chlorophenyl)-1,1,1-trifluoropentan-3-yl)-1H-indazol-4-amine

Procedure

A mixture of the product of Step E (80 mg, 0.17 mmol) and 4 N HCl/MeOH (2 mL) was stirred at room temperature for 2 h. After removing the solvent, the residue was dried in vacuo to give the title compound as colorless oil. LC/MS m/z=368.1[M+H]+.

Workup

  1. customAfter removing the solvent
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-82951150060f44158cae793835a61f4a
Source dataset
uspto-grants-2015_01
Patent number
US08933113B2

Reaction notes

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