Nitromethane → HCID 72709582, compound

HRID 1427683Notes

Reaction equation

HRID 1427683 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[C:7]2=[O:12].[N+:13]([CH3:16])([O-:15])=[O:14]>O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[C:7]2([OH:12])[CH2:16][N+:13]([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 6375NitromethaneHCID 23023537-Bromoisatin

Product 1

HCID 72709582HCID 72709582, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

7-bromoisatin (0.113 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 24 hours. The obtained product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

Workup

  1. extractionThe obtained product was extracted with ethyl acetate
  2. custompurified by silica gel column chromatography
  3. customto afford pure product

Sources & evidence

ORD record
ord-8b35b516fb18404d89861cbda35430e2
Source dataset
uspto-grants-2015_01
Patent number
US08933248B2

Reaction notes

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