Nitromethane → HCID 72709586, compound

HRID 1427687Notes

Reaction equation

HRID 1427687 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].[N+:13]([CH3:16])([O-:15])=[O:14]>O>[OH:12][C:5]1([CH2:16][N+:13]([O-:15])=[O:14])[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([CH3:1])[CH:3]=2)[NH:7][C:6]1=[O:11]

Participants

4

Reactant 2

HCID 6375NitromethaneHCID 118405-Methylisatin

Product 1

HCID 72709586HCID 72709586, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

5-methyl isatin (0.08 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 50° C. for 24 hours. The product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

Workup

  1. extractionThe product was extracted with ethyl acetate
  2. custompurified by silica gel column chromatography
  3. customto afford pure product

Sources & evidence

ORD record
ord-5a81223c1b894cc580be446b9fbf104d
Source dataset
uspto-grants-2015_01
Patent number
US08933248B2

Reaction notes

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