Nitromethane → HCID 72709665, compound

HRID 1427688Notes

Reaction equation

HRID 1427688 reaction equation
[F:1][C:2]([F:16])([F:15])[O:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[C:7]2=[O:14].[N+:17]([CH3:20])([O-:19])=[O:18]>O>[OH:14][C:7]1([CH2:20][N+:17]([O-:19])=[O:18])[C:6]2[C:10](=[CH:11][CH:12]=[C:4]([O:3][C:2]([F:1])([F:15])[F:16])[CH:5]=2)[NH:9][C:8]1=[O:13]

Participants

4

Reactant 2

HCID 6375NitromethaneHCID 27327525-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione

Product 1

HCID 72709665HCID 72709665, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

5-trifluoromethoxy isatin ((0.115 g) and nitromethane (0.1 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 20 minutes. The obtained product was extracted with ethyl acetate and the solvent was removed to give pure product.

Workup

  1. extractionThe obtained product was extracted with ethyl acetate
  2. customthe solvent was removed
  3. customto give pure product

Sources & evidence

ORD record
ord-a865812a6ae44bcfae837f91497de6c7
Source dataset
uspto-grants-2015_01
Patent number
US08933248B2

Reaction notes

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