Nitromethane → HCID 72709669, compound

HRID 1427691Notes

Reaction equation

HRID 1427691 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([Cl:17])=[CH:14][CH:15]=2)[C:10](=[O:18])[C:9]1=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:20]([CH3:23])([O-:22])=[O:21]>O>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([Cl:17])=[CH:14][CH:15]=2)[C:10]([OH:18])([CH2:23][N+:20]([O-:22])=[O:21])[C:9]1=[O:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6375NitromethaneHCID 3704739HCID 3704739, compound

Product 1

HCID 72709669HCID 72709669, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

1-benzyl-5-chloroindoline-2,3-dione (0.135 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 6 hours. The obtained product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

Workup

  1. extractionThe obtained product was extracted with ethyl acetate
  2. custompurified by silica gel column chromatography
  3. customto afford pure product

Sources & evidence

ORD record
ord-f7beb4f712c14c51957571125c611efa
Source dataset
uspto-grants-2015_01
Patent number
US08933248B2

Reaction notes

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